GS-441524 is a small molecule nucleoside analog that undergoes intracellular phosphorylation under the action of cellular kinases in vivo to generate active triphosphate metabolites (NTP), which can compete with natural nucleotides in the body. , inhibiting RNA polymerase, interfering with the RNA replication of feline infectious peritonitis virus, thereby blocking the synthesis of feline infectious
Read MoreThere is a special medicine that can cure “feline belly”, this medicine is called “GS-441524” (“441” for short). Studies have shown that the cure rate of this drug for “feline belly” is as high as 80%. But unfortunately, “441” can only be bought through the black market. As for why it can only be bought
Read MoreFeline ascites is not a name for a disease, but a symptom. Cats generally have a small amount of fluid in their abdominal cavity to help lubricate, but if a cat produces a large amount of exudate in the abdominal cavity, ascites will form. There are many diseases that cause ascites in cats, including feline-transmitted
Read MoreFeline infectious peritonitis (FIP) is a disease caused by feline virus, which can be infected by cats of all ages, but mainly affects cats under 3 years old, especially cats aged 4-14 months. The disease mainly occurs in foster care, shelter, etc. and high-density breeding places where stray cats gather. The disease is typically endemic,
Read MoreThe purpose of the trial is to observe the clinical efficacy of GS-441524 on naturally infected feline infectious peritonitis (FIP) cases, and to provide reference for clinical medication. Twenty-five cats diagnosed with FIP at the Animal Hospital of China Agricultural University were recruited and randomly divided into a high-dose group (5 mg/(kg·d)) (12 cats) and
Read MoreBecause FIP is a variant of coronavirus, and coronavirus is transmitted between cats, as long as they have not been infected with coronavirus before, an “only child” cat raised indoors (a home environment with only one cat) is more likely to be infected with FIP. It is relatively small. In this case, the infection is
Read MoreOne of the reasons why FIP (Feline Infectious Peritonitis) is terrible is that there is no simple diagnosis method (unlike canine distemper, small, although not easy to treat, but at least it is easy to know whether it is sick). ELISA (enzyme-linked immunosorbent test), IFA (immunofluorescence detection), and Virus-neutralization test (virus neutralization test) can only
Read MoreTo talk about the most terrifying cat disease, it must be the notorious feline infectious peritonitis. The cure rate is less than 5%, so it can be said to be a terminal disease of cats. There is currently no medicine to cure the disease. Supportive care is often used to prolong the life of cats.
Read More【Mechanism of action of GS-441524】GS-441524 is a small molecule nucleoside analog that undergoes intracellular phosphorylation under the action of cellular kinases in vivo to generate active triphosphate metabolites (NTP), which can compete with natural nucleotides in the body. , inhibiting RNA polymerase, interfering with the RNA replication of feline infectious peritonitis virus, thereby blocking the
Read More